Escherichia coli hijack Caspr1 receptor to invade cerebral vascular and neuronal hosts
نویسندگان
چکیده
منابع مشابه
Phylogenetic group determination of faecal Escherichia coli and comparative analysis among different hosts
Phylogenetic analysis has shown that Escherichia coli is composed of four main phylogenetic groups (A, B1, B2 and D). Characterization of phylogenetic groups is of clinical interest, as group A and B1 generally associated with commensals, whereas most enteropathogenic isolates are assigned to group D, and group B2 is associated with extra-intestinal pathotype. One hundred E. coli strains recove...
متن کاملHow bacterial pathogens colonize their hosts and invade deeper tissues.
Bacterial pathogens have evolved a wide range of strategies to colonize and invade human organs, despite the presence of multiple host defense mechanisms. In this review, we will describe how pathogenic bacteria can adhere and multiply at the surface of host cells, how some bacteria can enter and proliferate inside these cells, and finally how pathogens may cross epithelial or endothelial host ...
متن کاملHuman sepsis-associated Escherichia coli (SEPEC) is able to adhere to and invade kidney epithelial cells in culture
The adhesins of extraintestinal pathogenic Escherichia coli are essential for mediating direct interactions between the microbes and the host cell surfaces that they infect. Using fluorescence microscopy and gentamycin protection assays, we observed that 49 sepsis-associated E. coli (SEPEC) strains isolated from human adults adhered to and invaded Vero cells in the presence of D-mannose (100%)....
متن کاملCerebral histamine: indications for neuronal and vascular regulation.
Seventy-two years ago, Sir Henry Dale discov ered that histamine (8-iminazolylethylamine) was a constituent of most mammalian tissues and was a potent agonist on a variety of biological target cells (Dale and Laidlaw, 1910; Dale, 1953). It was suggested that this amine may have a transmitter role in several organs, conveying messages from cells where it was synthesized or stored to adjacent ce...
متن کاملIn silico Study of Toll-Like Receptor 4 Binding Site of FimH from Uropathogenic Escherichia coli
Introduction : The innate immune system as the first line of defense against the pathogens recognizes pathogen-associated molecular patterns (PAMPs) by Toll-Like Receptors (TLRs). Interaction of bacterial PAMPs by TLRs results in activation of innate and acquired immunity. FimH adhesin, a minor component of type 1 fimbriae encoded by Uropathogenic Escherichia coli (UPEC) is a PAMP of TLR4 tha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Microbial Cell
سال: 2018
ISSN: 2311-2638
DOI: 10.15698/mic2018.09.647